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Last reviewed: March 7, 2012.Inordinate feelings of worthlessness or guiltWhat Are the Causes of Depression in Senior CitizensGartlehner G, Hansen RA, Morgan LC, et al. Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis. Ann Intern Med 2011; 155:772.

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Understanding the underlying cause of your depression may help you overcome the problem. For example, if you are depressed because of a dead end job, the best treatment might be finding a more satisfying career, not taking an antidepressant. If you are new to an area and feeling lonely and sad, finding new friends at work or through a hobby will probably give you more of a mood boost than going to therapy. In such cases, the depression is remedied by changing the situation.Depression is a common mental disorder, affecting at least 1 in 20 people in some point in their lives. Depressive illness is characterised by an over whelming and peristent low mood that may lasts for several months. Depression interfers with a person's relationships and their ability to work effectively. As well as these changes in feelings and thoughts, depression causes difficulty in getting off to sleep, and waking in the night. Poor appetite is another feature of the depression.Depression and anxiety can be harder to treat than either condition on its own. Getting control might take more intensive treatment and closer monitoring, says Ian A. Cook, MD, the director of the Depression Research Program at UCLA. Here are some tips.MAO inhibitors  — MAO inhibitors are often avoided because of their potential to precipitate enhanced sympathetic activity and severe hypertension with the concomitant ingestion of tyramine-containing foods (eg, fermented cheeses, imported beer, Chianti, champagne, some other wines, soy sauce, avocados, bananas, overripe or spoiled food, and any fermented, smoked, or aged fish or meat). The hypertensive reaction is dose-dependent and can be exacerbated if the patient is also taking a sympathomimetic drug.